The "Guild Wars" in the title refers to the back story of the game, where powerful houses fought amongst each other, causing much strife in the various lands of Tyria. In the current game setting, guilds are basically a way of indicating who you associate with, and provides a framework for organized group vs group fighting.
It's already bad enough that whether your Kurzick/Luxon affects which outposts you can buy/sell at, and I wouldn't like to see more restriction added. I also wouldn't like to see guild decisions impacting individual play too much.
In general, the in-game historical significance if guilds is enough...
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